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УРЕМИЯ

UREMIA

Uremia is a clinical syndrome characterized by elevated blood urea levels. It is based on metabolic abnormalities, fluid imbalance, electrolytes and hormones associated with the deterioration of renal function.
Uremia is more common in patients with chronic kidney disease (CKD), especially in the later stages of CKD or in acute kidney damage if the loss of kidney function is rapid. Urea itself has both direct and indirect toxic effects on a number of tissues.

Urea is synthesized in the liver and is the end product of protein metabolism. It is transmitted from the liver through the blood to the kidneys, where it is excreted in the urine. However, when kidney function is impaired, waste products and toxins such as creatinine and urea accumulate in the blood and cannot be effectively filtered and removed. If uremia is left untreated, this condition is life-threatening.

Symptoms:

Tingling and numbness of the hands and feet – neuropathy

General fatigue and low energy

Nausea, vomiting and loss of appetite

High blood pressure

Swelling of the ankles

Dry skin and itching

More frequent urination

Chronic kidney disease and factors leading to kidney failure and uremia are:

Congenital anomalies of the kidneys

Polycystic kidneys

Diabetic nephropathy

Congestive heart failure and arrhythmias

Chronic pyelonephritis

Kidney stones, enlarged prostate

Taking certain medications and corticosteroids

 

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